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This represents all the TSE-positive cases recorded during 2002 2003 by active surveillance (>160,000 brain samples originating from slaughterhouse and rendering plants screened by rapid tests) and is thus representative of the diversity of French isolates.
In this study, we used 2011 brain samples originating from 439 individuals to provide the most reliable and coherent information on the regional expression, splicing and regulation of MAPT available to date.
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The complete subdivision of samples originating from different regions of the brain by hierarchical clustering suggests significant differences in gene expression patterns between these brain regions.
Post-mortem brain samples were acquired through the Autism Tissue Program (http://www.atpportal.org), with samples originating from two different sites: the Harvard Brain Tissue Resource center and the NICHD Brain and Tissue Bank at the University of Maryland.
As shown in Figs. 1a and 2, samples originating from the left and right hemispheres of a certain region from the same rat brain were no closer related to each other than to corresponding samples from the other brains.
The sequencing of DNA samples originating from Asia and from museum eggshells was outsourced to Ecogenics GmbH, Zürich-Schlieren, Switzerland.
The analysed material includes field logs and sediment samples originating from the Juvdalskampen section, central Spitsbergen.
The tc-positive isolates were cultured from 13 soil samples originating from the northern United States, Sweden, Norway and Iceland.
Retina/brain DNA samples originating from the same mouse were pooled.
The laboratories have categorized the samples mainly as "diagnostic samples originating from cases of infection".
Four RNA samples originating from naturally ovulating females, 11 RNA samples originating from hormonally-induced females and 14 RNA samples originating from photoperiod-manipulated females were used for microarray hybridization according to the following procedure.
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