Dr. Ann McKee, a co-director at Boston University's Center for the Study of Traumatic Encephalopathy, recently published a study with colleagues that examined, posthumously, brain samples of 85 people who had repeated mild brain trauma as opposed to concussions.
The latest study was carried out on the stored brain samples of eight patients who had undergone tissue grafts in Austria and Switzerland but who had died from another brain disease, Creutzfeldt-Jakob disease (CJD), which is now known to have been transmitted during the operation involving nerve tissue taken from human cadavers.
In our CLP model, the brain samples of the septic rats showed markedly increased gliosis.
In our study, significantly elevated levels of C5a were also found in the brain samples of the rats with sepsis.
In line with previous studies, the brain samples of the septic rats showed concomitantly increased C5a, C5a receptor expression, and apoptosis.
By contrast, no or very few apoptotic cells and reactive glial cells were observed in the brain samples of the control, sham, and CLP rats treated with IgG or IgGAM (Fig. 5a, b).
mRNA expression levels of apoptotic molecules Bax and NF-κB were significantly lower in the brain samples of IgG- and IgGAM-administered rats as compared to those of the control, sham, and CLP groups.
Brain samples of five different hibernation-states (euthermy, early torpor, long torpor, early arousal and long arousal) were compared in arctic ground squirrels and Syrian hamsters.
The result of enzyme activities was assessed in cortical brain samples of arctic ground squirrels (EU, n = 4; TL, n = 4, AL, n = 4).
The microRNAs, let-7a, let-7c, miR-16, -19b, -23a, -103, -106b, -185, -191, -320 and -451 that were present in both the blood and brain samples of rodent stroke (MCAo)[11] model have also been detected in the human blood samples used in this study.
Using nested PCR targeted to gag genomic sequences, we screened DNA samples from: (i) peripheral blood of 102 ASD patients and 97 controls, (ii) post-mortem brain samples of 20 ASD patients and 17 sex- and age-matched controls, (iii) semen samples of 11 fathers of ASD children, 25 infertile individuals and 7 fertile controls.
