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Now a study that looks at postmortem brain samples from humans, chimpanzees, and macaques collected from before birth to up to the end of the life span for each of these species has found a key difference in the expression of genes that control the development and function of synapses, the connections among neurons through which information flows.
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However, the study of its levels in Alzheimer's disease was scant because of Alzheimer's posthumous diagnosis and the inability to collect brain samples from living humans.
The finding was in accordance with the expression experiments, in which lower expression levels of the distal SLC6A4 form were observed in female brain samples from both humans and mice.
Freshly frozen brain samples from deceased human subjects were collected at autopsy following informed consent from the next of kin under a protocol approved by the local ethics committee.
Our gratitude to; Maree Webster for helping obtain the human brain samples from the Stanley Brain Collection, Björn Owe-Larsson and Anne-Sofie Johansson for providing the primary human fibroblast cultures.
Since little is known about TMEM106B and its expression in human brain, we performed immunohistochemical studies of TMEM106B in postmortem human brain samples from normal individuals, FTLD-TDP individuals with and without GRN mutations, and individuals with other neurodegenerative diseases.
We studied the effect of PD risk-associated variants at SNCA 5' and 3'regions on SNCA-mRNA levels in vivo in 228 human brain samples from three structures differentially vulnerable to PD pathology (substantia-nigra, temporal- and frontal-cortex) obtained from 144 neurologically normal cadavers.
Further investigations on similar lines with in vivo models as well as post mortem human brain samples from drug abusing HIV/AIDS population are warranted.
Analysis of DNA-binding of NF-κB (p65/p50 heterodimer) and the p50 homodimer as well as NF-κB proteins and mRNAs was performed in postmortem human brain samples from 15 chronic alcoholics and 15 control subjects.
We also collected human brain samples from one new born male (1 month) and two adult males (28 years, 40 years), and multiple tissue samples from a female embryo (36 weeks).
The coup de grace was the investigators' demonstration of aberrant nuclear morphology in neurons in the hippocampal dentate gyrus of post-mortem human brain samples from individuals with PD, a pathological feature not previously described in PD.
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CEO of Professional Science Editing for Scientists @ prosciediting.com