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In brain samples from animals between 10 17 months of age (Table 2), WB might have missed positive diagnosis in 4 preclinical cases, since these analyses possibly obex parts lacking dorsal motor nucleus of the nervus vagus where the first positivity can be found [ 25].
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Although IDUA activity was undetectable in brain samples from transplanted animals, the mean level of GAGs detected was slightly although not significantly lower than that observed in untreated animals in all portions of the brain including the olfactory bulb, cerebellum, hippocampus, striatum, cerebral cortex, and brainstem and thalamus.
Test results of brain samples from all animals were positive for macaque-adapted BSE by Western blot analysis.
To investigate differential mRNA expression in BSE-infected macaques we used brain samples from 6 animals that were intracranially challenged [ 33].
The right and left brain samples from all animals were lysed on the same day in 1×lysis buffer (Cell Signaling Technology) with protease inhibitors (Roche) and centrifuged at 17000 g for 15 min at 4°C.
Brain samples from resuscitated animals were collected at 30 min (Rosc30 and MB30 groups), 60 min (Rosc60 and MB60 groups) or 180 min (Rosc180 and MB180 groups) after ROSC.
It was able to detect viruses in brain samples from experimentally infected animals.
In addition, we tested the interactive effects of several PCB congeners (three or more) found in environmental samples such as human milk and blood, contaminated fish, and brain samples from PCB-treated animals.
Independent brain samples from 34 subjects and animal studies were used to control for the potential confounding effects of comorbidity with alcohol.
After conducting maze tests, the neuroscientist Fred H. Gage and his colleagues examined brain samples from the mice.
A 2013 study compared brain samples from mentally healthy organ donors with samples from donors who were clinically depressed at the time of their deaths.
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