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This review highlights the advancements in nanoscience and nanotechnology to design and develop specific size therapeutic cargo for efficient navigation across BBB so as to recognize and eradicate HIV brain reservoirs.
Similarly, the HIS mouse models cannot be used to study brain reservoirs of HIV infection because they do not contain HIV-infected microglia or astrocytes.
In addition, the HIS-CNS mouse will provide a novel model that could be used for evaluating the effectiveness of new strategies to eradicate brain reservoirs of HIV and for evaluating the effects of long-term antiretroviral therapy on the brain.
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Knowledge of the potential brain plasticity reservoir after brain damage constitutes a prerequisite for an optimal rehabilitation strategy.
Whereas Prozac-type SSRI antidepressants keep your brain from emptying reservoirs of serotonin too quickly, Ecstasy floods your brain with the stuff.
The SIV/macaque model is ideal to measure viral cellular reservoirs including brain [12,13].
The solubility of oxygen in water is very low and there is no reservoir in brain, so oxygen extraction would have to rise to provide more oxygen to tissue until delivery increases.
Therefore, we hypothesized that the normal tissue stem cells niche in the brain may be a reservoir for CSCs from where they initiate and repopulate a tumor and that irradiation of the potential cancer stem cell niches in the brain would improve patient survival.
Other reservoirs, particularly certain brain cells, would not have been affected directly and in Mr Brown's case checking his brain to find out what is going on would be grossly unethical.Clearly, it is dangerous to draw conclusions from a single example.
Thus, screening, monitoring, and elimination of HIV reservoirs from the brain remain a clinically daunting and key task.
His work won 19 awards, including the Special HIV Cure Prize given out at the 2013 International AIDS Society meeting in Malaysia; the award recognized work in which he identified mechanisms that allow HIV to establish reservoirs within the brain.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com