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SAM analysis revealed a significant downregulation of PTEN expression in patients with brain relapse compared with patients with bone relapse (Additional file 7).
In addition, we found, by using the same data set, a significant downregulation of PTEN expression among primary tumor patients with brain relapse compared with patients with bone relapse, but not to the lung.
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Four of the six patients with positive [(18 F]FDG-PET scans after chemotherapy experienced relapse compared with just three of 75 patients with negative [(18 F]FDG-PET scans.
A positive PCR test at 3 months post-BMT was not statistically significantly associated with an increased risk of relapse compared with PCR- negative patients.
AIs are better at minimizing risk of early relapse compared with tamoxifen.
35 (31.0%) male patients suffered from tumor relapse compared with 28 (25.9%) cases in women.
For example, certain subgroups may accrue more costs due to side effects from adjuvant therapy before relapse, with a lower monthly cost after relapse compared with other subgroups.
Of the 13 who had HIV coinfection, 8 (62%) had a relapse, compared with 7 (27%) of the 26 HIV-negative patients who had a relapse.
AI at PTEN loci was found significantly more often in brain metastases (52%) and primary tumors with a brain relapse (59%) compared with primary tumors from patients without relapse (18%; P = 0.003) or relapse other than brain tumors (12%; P = 0.006).
However, the mean SDS after PVI were slightly but not significantly higher in patients with and AF relapses compared with patients without relapses (no relapse n = 11 2.4 ± 1.5 vs. relapse n = 4 2.7 ± 3.1; p = ns).
The correlation of the BD-L signature with both brain metastases and BRCA1 mutation is consistent with the published literature as BRCA1 mutation carriers are reported to have an increased prevalence of breast cancer brain relapse as compared to noncarriers [ 8, 31].
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