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In this study, we estimated the ATB in brain regions using a pixel-wise approach based on the differences in estimated CBF values derived from the ARG and BFM using clinical C15O2 PET data.
SUV normalized time activity curves (TACs) were generated and 11C-BUP binding potential [BPND, i.e. the ratio of the total receptor density (Bmax) on the equilibrium dissociation constant (KD)] were modeled in different brain regions using a simplified reference tissue model with cerebellum as reference region.
Carefully, the neurosurgeon places the electrodes in the desired brain regions using a set of coordinates determined by an image of the patient's brain.
However, most clustering approaches have clustered over brain regions, using a parcellation of the cortex in a number of fixed regions, making the spatial resolution of these methods limited to a regional scale.
We corrected for multiple testing across the eight brain regions using a Bonferroni correction.
Protein levels were compared between genotypes, sexes, and brain regions using a three-level mixed effects model and the Benjamini-Hochberg correction for multiple testing.
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Different grid and dissector sizes were determined according to each brain region using a CE value ≤0.1 to indicate sampling efficiency.
Correlations between ADC values of each brain region used a Pearson's correlation.
Under such conditions, the expression of eNpHR in specific brain regions using viral vectors should be quite useful.
In two studies the expression of human BDNF mRNAs with alternative 5′ exons was examined in a few adult brain regions using RT-PCR [19,26].
For example, Surget et al. [ 45] showed specific transcriptome changes in different brain regions using the unpredictable chronic mild stress paradigm, a model of depression based on socioenvironmental stressors.
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