The neuronal states, which represent the neuronal population activity of the modeled brain regions, change in time according to the system's connectivity and experimentally controlled inputs u.
Using rudimentary indicators such as the position of lesion sites (Schüz and Palm, 1989), or observations of how the brain filled the skull (O'Kusky and Colonnier, 1982), gave no precise value for how any brain region changed in volume during the preservation process.
These adverse effects may be due to changes in blood flow in particular brain regions and changes in neurons caused by overactivation, but it is not clear what mechanisms are involved.
However, it is important to distinguish between alterations in levels of activity in individual brain regions from changes in connectivity between regions.
(B ) Overlap of the brain regions with changes in CMRglc, rCBF, and functional connectivity.
Of course, any particular behavior supported by mrPFC will depend on its interactions with other brain regions, and changes in brain development associated with ASD are unlikely to affect mrPFC alone.
The most robust evidence, showing specificity of structural changes to training, task and brain region, shows changes in anterior hippocampal volume with exercise in elderly participants.
It is not clear whether the observed responses to TBI are beneficial or not, but these results suggest brain region-specific changes in arachidonate metabolism due to alterations in the enzymatic machinery available at the time.
The reason for the differential, brain region-specific changes in BDNF expression is likely that the neuronal circuits in the different regions are involved in coordinating complex behavioral and neuroendocrine responses to food intake or deprivation.
This transgenerational anxiety behavior was also examined on a molecular level to identify brain region specific changes in different gene expression and gene networks associated with the behavior [ 23].
