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Each region corresponds to a coursed grained brain region, which is recurrently connected.
Laser confocal microscopy in transgenic lines expressing n-syb-eGFP showed that fluorescence is largely localized in the mushroom bodies, the brain region involved in associative learning and memory, and to the antennal lobe of the brain region, which is responsible for olfactory function [Fig. 2A].
This distinction can be seen most prominently in the response recorded over the right occipito-temporal brain region, which is near the back of the brain.
Together with let-7c, both miR-125 and miR-99 are over-expressed by at least 50% in the foetal hippocampus of individuals with Down syndrome compared to age and sex matched controls suggesting that miRNAs are playing an important role in this brain region, which is pertinent for learning and long-term memory formation [ 51].
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This reduction in histone methylation was mediated through the repression of G9a in this brain region, which was regulated by the cocaine-induced transcription factor ∆FosB.
The second largest gene set was allocated to the brain region globus pallidus for both AD-iPS neuronal cells, a brain region which was reported to be involved in Alzheimers disease [ 51].
Indeed, clinical symptoms rather reflect affected brain regions, which is especially exemplified in the heterogeneity of clinical FTLD.
As mentioned in the introduction, many brain modules were found to be highly preserved across the three brain regions, which is why they received the same color label.
Based on these recent findings, it is proposed that we are now at the verge of applying these new analytical frameworks in human functional brain imaging in order to functionally fractionate brain regions which are conventionally modelled as functional units, e.g. areas within the posterior parietal cortex, into distinct subdivisions with different functional contributions.
During the moments of greatest suspense, activity in the frontal parietal brain regions, which are devoted to orchestrating attention, flared up in healthy participants and became increasingly intense until the end of the film, when the boy nearly hits the family maid with a real bullet.
Symptoms result from the degeneration of brain tissue, seen as shrinkage of certain brain regions, which are involved in cognitive processes, learning, and memory formation (reviewed in [1]).
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com