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Analyses of a single brain region at a time used region definitions derived from the Anatomical Automatic Labeling (AAL) system [10].
The Bayesian Estimation of Temporal Regulation (BETR) algorithm was used to identify the differentially expressed genes (DEG) for each brain region at a False Discovery Rate (FDR) < 0.05.
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First, the brain networks were constructed by parcellating the entire brain into 90 brain regions at a coarsely regional level.
Although a main effect of age group was found before correction for multiple comparisons (age 8 > age 9 > age 10) for the brain regions at an early stage of cortical auditory processing (i.e., the primary and auditory association cortices, and the superior/middle temporal gyri), none of the 6 ROIs reached significance after Bonferroni correction.
Overall, the analyses of global gene expression revealed significant differences between brain regions at all ages, and changes within both regions with postnatal age.
We observed no atrophy of any of these brain regions at any of these three time points (Additional file 1: Figure S1A).
In a previous study, Maguire used brain scans to show that a brain region at the rear of the hippocampus known to be involved in learning directions and locations is enlarged in London taxi drivers.
Both atypical BSE types were readily detectable as BSE by current confirmatory methods using the medulla brain region at the obex, but making a clear diagnostic distinction between the forms was not consistently straightforward in this brain region.
For each antibody and brain region at least 2 assays were performed.
However, the neuronal cytoarchitecture was only studied in the hippocampal formation (ERC plus all the hippocampal subfields) because it is in this brain region where cytoarchitectural anomalies have been reported in schizophrenia [57] and because this is the targeted brain region at E17.
Unfortunately, TgCNRD8 did not reveal spine loss in the brain region at the age studied.
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