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The evolution of Myotragus has been accurately tracked through an impressive fossil record documenting (1) decrease in size, (2) brain reduction, (3) changes related to locomotion, and (4) reduction in the number of incisors and premolars.
GSH is the major free radical scavenger in the brain; reduction of GSH level promotes cellular vulnerability towards oxidative stress.
Not only did the signal peptide enhance secretion, but also the BBB binding domain permitted rescue of sulfamidase activity in the brain, reduction of neuropathology, and a restoration of behavior.
It plays a critical role in the acid-base balance [ 2, 3] and its altered activity is associated with the development of pathophysiological conditions such as gastroesophageal reflex disease (GERD), increased osteoclast activity, increased amyloid beta production in the brain, reduction in brain acetylcholinesterase activity, and alteration in spatial and chromatic visual perception [ 4– 11].
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Typical lower FDG metabolism was shown in the precuneus, posterior cingulate, and temporal and parietal cortex with progression to whole brain reductions with increasing disease progress in AD brains [50, 51].
Mean counts of plaques in the neocortex and the hippocampus of NIr-treated APP/PS1 brains were lower than mean counts in untreated APP/PS1 brains (reductions >30%).
Rather than overall brain size reduction, it seems more likely that reductions of particular components of the forebrain, such as the amygdala or other components of the limbic system, play the important CNS roles in tameness.
Oxidative damage induced to brain implicates reduction in brain energy metabolism which causes more microvascular constriction and reduction in blood flow that leads to microgliosis.
The mechanism of dementia can be explained by direct brain compression, reduction in whole brain cerebral blood flow (CBF) and generalized astrocyte reactivity.
After acute infection, virus is not completely cleared from the brain despite reduction in viral replication.
yata null mutants showed phenotypes that included developmental abnormalities, progressive eye vacuolization, brain volume reduction, and lifespan shortening.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com