Sentence examples for brain penetration from inspiring English sources

Lisinopril, one of the main comparators, is not a brain penetrant, although whether brain penetration increases with dementia is unknown.

Also, their brain penetration has been assessed (PAMPA-BBB assay).

Notably there was no apparent brain penetration of radiolabelled metabolites and no defluorination.

11 C]GSK931145 demonstrated good brain penetration and usefulness for GlyT1 occupancy study in monkeys [21].

Brain penetration of the ligand did not increase after P-gp and BCRP blockade.

Brain penetration is lower for other kynurenine metabolites (reviewed by Schwarcz et al., [19]).

For PD treatment, limited brain penetration of drug is a major concern.

Moreover, it has demonstrated desirable water solubility, PK profile, and moderate brain penetration.

A pharmacokinetic study of compound 1 in vivo revealed good bioavailability and brain penetration in rats.

As a representative example, radiolabeled 6 was examined in vivo and showed reasonable brain penetration.

The receptor occupancy test in the rat cortex revealed favorable brain penetration of these compounds.