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The SPA network is distinct from the brain pathways that regulate purposeful activity, although the final common pathway leading to movement is clearly shared.
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In addition to higher brain descending pathways that regulate the motor act of coughing, it is now well established that higher order sensory pathways receive inputs from the airways and play an important role in generating cognitive sensory responses to airways irritation [ 12- 14].
The studies reported here provide the first step in identifying these pathways and our model will be used to identify additional cellular signaling pathways that regulate infection and inflammatory changes in the brain.
Using systems biology approaches, we are identifying immune pathways that regulate immune metabolism and immune responses at the brain interface.
Our studies also will serve as a springboard to identify genes and pathways that regulate spinal cord NSC proliferation and differentiation pathways that may be different from those utilized by brain NSCs.
Guarente, L. & Kenyon, C. Genetic pathways that regulate ageing in model organisms.
However, some of the pathways that regulate these events are poorly understood.
Figure 3: Signalling pathways that regulate human prostatic basal stem/progenitor cell activity.
Other pathways that regulate EMT39 such as Wnt and Notch remained unaffected (Supplementary Fig. 11e, f).
We are interested in the signal transduction pathways that regulate development and cancer.
We are studying signaling pathways that regulate oxidative stress responses and cancer cell growth.
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