Freed from the limits of vision and sensation, the scope of this reality is beyond measure; it is a reality that nurtures and is nurtured by human minds; it is made of meanings that only the semiological system of language can produce, and that can only be 'read' by minds free of brain pathology and familiar with the functional varieties of that language.
Within the context of the Rotterdam Scan Study, a standardized image analysis workflow is being developed, validated and applied to all imaging data, to enable the objective, accurate, and reproducible extraction of relevant parameters describing brain anatomy, possible brain pathologies, and structural and functional brain connectivity from multispectral MRI data.
Furthermore, hCDR1 reduced brain pathology and improved behavior parameters in mice with central nervous system manifestations.
Whether these alterations mirror brain pathology, and how they relate to clinical symptoms, remain open questions.
Brain delivery led to an effective amelioration of the overall brain pathology and behavioural phenotype in treated MPS-IIIA mice.
The mechanistic link between the observed brain pathology and the absence of aspartoacylase is unclear.
Few studies investigated the relationship between brain pathology and nutritional status in AD patients.
This "glucocorticoid cascade hypothesis" may also be relevant to exploration of depression-related brain pathology since functional changes of HPA axis as well as alterations in brain structures, specifically hippocampus, have been consistently reported in major depression (see [ 14] for review).
The current study using an improved VGLCM method can explore whole-brain pathology and brain-behavioral relationships.
Asuni, A. A., Boutajangout, A., Quartermain, D. & Sigurdson, E. M. Immunotherapy targeting pathological tau conformers in a tangle mouse model reduces brain pathology with associated functional improvements.
