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For example, miRNAs modulate differentiation of the hematopoietic lineage [17] and several ES cell-specific miRNA have been identified [18], [19] miRNAs have also been shown to regulate brain morphogenesis in zebrafish [20] and in animal development [21].
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Eph/ephrin signaling has been implicated in notochord morphogenesis in zebrafish [12], [13], though it is unknown which step of notochord development is regulated by this signaling.
Hdacs and Polr3 are required for exocrine pancreatic epithelial proliferation during morphogenesis in zebrafish.
We examined a role of Wnt-5 signaling in pancreatic islet morphogenesis in zebrafish and mouse embryos.
During retinal morphogenesis in zebrafish, the expression of mdka and mdkb are differentially regulated (Calinescu et al., 2009a; Figure 2).
Hdac1 is required for epithelial proliferation and normal growth of exocrine pancreas during morphogenesis in zebrafish (Noel et al., 2008; Zhou et al., 2011).
MicroRNA injection can also be used in rescue experiments, for example, in a study on the role of miR-430 on zebrafish brain morphogenesis.
In view of the unique tissue expression profile of PRL2 in zebrafish, we have also examined the possible involvement of zfPRL2 on eye and brain development in zebrafish.
We found that BPA exposure influences DV patterning, somite formation, and brain development in zebrafish embryos.
Increased gene dosage results in brain morphogenesis defects, low BDNF levels and mnemonic deficits in these mice.
In summary, localized, transient, and constitutive expression of miRNAs in teleost brain indicates their function in brain morphogenesis and maintenance of distinct subregions and cell types.
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