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Identification of parasite antigen cross-presented by brain microvessels would be a significant advance towards understanding the pathogenesis of CM.
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Barger also suggested that with systolic surges of blood pressure these microvessels would be prone to rupture leading to IPH.
Anybody with a brain would be suspicious.
If Ang1 modifies permeability coefficients in intact microvessels via modification of inter-endothelial cleft molecules, then changes in continuous microvessel water permeability (LP), but not fenestrated microvessel LP, would be expected in response to Ang1.
Brain perfusion with saline was performed to remove the blood from the brain microvessels before decapitation because the radioactivity in brain microvessels could be a confounding factor in the correct interpretation of the data from brain parenchyma.Under urethane anesthesia, a 1 1.5 cm-long incision was made with the scissors midway between the trachea and esophagus and the shoulder of the rat.
As vascular mural cells of brain microvessels, pericytes are positioned within the neurovascular unit among endothelial cells (ECs), astrocytes, and neurons.
However, Wang et al. recently detected Cyp1a1 protein expression in isolated rat brain microvessels which was increased by TCDD [ 34].
When brain microvessels are isolated from adult mammalian brain and brain endothelial cells are cultured from these vessel fragments, they retain many key features of the BBB phe-notype.
Brain microvessels were obtained as described previously [18].
To explain Aβ enhanced clearance across the BBB, brain microvessels were isolated for analysis.
13 After removing the leptomeninges from the brain, microvessels were isolated out of the grey matter.
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