Sentence examples for brain microenvironment in from inspiring English sources
This suggests the influence of the brain microenvironment in transcriptional regulation and, thereby, the physiology of glioma cells in vivo.
An alternative explanation is that MyD88-positive leucocytes infiltrating the brain parenchyma do not receive a requisite signal(s) from the brain microenvironment in the absence of MyD88, culminating in ineffective bacterial neutralization.
While controlling the passage of molecules between the brain blood circulation and the brain microenvironment in the healthy brain, the BBB may also contribute to the pathogenesis of several neurological disorders such as neurodegenerative diseases, under conditions of abnormal functioning [ 1].
As a result of this adult brain microenvironment and in contrast to the developmental BBB, the adult BBB boasts an elevated TEER, measured at average values between 1000 2000 Ωxcm (and maximum values up to 6000 Ωxcm) and a correspondingly lower passive permeability to molecular tracers [ 21, 25, 26].
Importantly, the peptide-injection model appears to replicate the changes in cellular properties and brain microenvironments evident in inflamed brain in the progression of AD pathology.
Brain microenvironment is important in determining survival, migration and differentiation of exogenously transplanted progenitor cells and stem cells.
Leakage of plasma proteins, including fibrinogen and IgG into the brain microenvironment was observed in patients with m.3243A>G and m.8344A>G mutations.
Given the aforementioned complex intercellular interplay that defines the embryonic and adult neurovascular unit, one can imagine that removal of BMECs from their brain microenvironment and growth in culture can lead to loss of BBB phenotype.
Through ex vivo NSC injection, continuous expression of the transduced genes in the brain microenvironment of WT and Mecp2tm1.1Bird+/− female mice was monitored and observed for 3 weeks.
Activation of microglia in response to alterations in the brain microenvironment is a dynamic process [ 1], characterized by a change in the microglial shape and phagocytic behaviour.
The fact that diffuse infiltrative glioma cells tend to blend in extensively in the brain microenvironment makes it hard to plan an effective counterattack.
