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The impact of sepsis on the brain microcirculation is not well defined.
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However, the CSF microcirculation is not a quantitatively important pathway for drug distribution into the brain from the CSF compartment.
Whether RRI reflects the systemic circulation or renal microcirculation is not well known.
Patients whose microcirculation is not responsive to such resuscitation, however, have a poor prognosis [ 2].
However, current technology for monitoring the microcirculation is not yet ready for the clinical arena and further clinical trials in different patient groups are needed before the microcirculation can really present itself as a window to monitor and treat shock.
Moreover, changes in the cerebral microcirculation were not related to changes in MAP, CI or lactate, suggesting that these alterations in the brain may occur even when global perfusion pressure is maintained, such as in non-hypotensive conditions.
Markers of the microcirculation were not.
However, as the relationship between systemic hemodynamics and microcirculation are not straightforward [25, 26], the assessment of microcirculation might also improve our understanding of the effects of passive mobilization beyond changes to systemic hemodynamics.
Its effects on oxygen delivery and microcirculation are not well known.
The brain is not the mind.
"The brain is not a simple machine".
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com