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Sepsis-induced changes in brain microcirculation have been described using the same technology [ 25, 26].
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Adjunctive devices for PCI to protect the microcirculation have been developed.
Multiple approaches for the assessment of the microcirculation have been suggested.
Also, impairments in intramuscular microcirculation have been demonstrated in painful muscles [15].
Different therapeutic interventions for improving pancreatic microcirculation have been evaluated in the last years [ 9, 12- 16].
The influence of brain death over microcirculation has been studied by Simas et al. [ 42] proving that mesenteric microcirculation is decreased during brain death measured with in vivo microscopy.
The relevance of the disruption of the microcirculation has been reported during septic shock in the clinical setting.
The sublingual microcirculation has been the most extensively studied in patients with critical illness and sepsis.
The detected microcirculation has been shown to follow the accepted anatomical structure.
However, impaired villous microcirculation has been advocated as the causal phenomenon in the latter [ 33].
Intravital video microscopy of pial microcirculation has been used to observe the effects of MTL and HTS on the interaction between polymorphonuclear and endothelial cells in a model of trauma-induced brain inflammation [ 30], but changes in cortical perfusion have not been evaluated.
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