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Magnetic resonance spectroscopy can identify brain metabolic changes in perinatal asphyxia.
Magnetic resonance spectroscopy can identify brain metabolic changes in perinatal asphyxia by providing ratios of metabolites, such as choline (Cho), creatine (Cr), N-acetyl aspartate (NAA) and lactate (Lact) [Cho/Cr, Lact/NAA, etc.].
It is important to mention that ICP increases and PbtO2 decreases did not result in brain metabolic changes in our patients, most likely due to the short duration of these episodes as all of these parameters were predefined as trial-failure criteria.
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Although serious brain metabolic changes were not observed, related side effects may overcome clinical benefit in severely brain injured patients and the information gained by multimodal neuromonitoring can be used to safely conduct IS-trials in certain patients and disease states.
In this prospective observational study, we investigated the effect of interruption of sedatives and analgesics on hemodynamic and brain metabolic changes.
Meanwhile, another longitudinal study of brain metabolic changes during the conversion from aMCI to AD, found that converters had a significantly greater metabolic decrease in the left ACG than non-converters [ 53].
The absence of differential methylation in the brain may be explained by counter regulatory mechanisms, which spare the brain tissue from metabolic changes in the rest of the body.
AUDs may be related to dementia via a number of mechanisms including brain damage due to toxic effects of alcohol, metabolic changes in the brain, neurotransmitter imbalances, and nutritional deficiency.
We have evaluated the effectiveness of AP39, AP123 (and respective their control compounds) at preventing/reversing hyperglycaemia (HG -induced oxidative stress, and metabolic changes in brain microvascular endothelial cells in vitro.
Chronic HIV infection is associated with metabolic changes in brain, even among patients on suppressive ART [ 27, 35– 35].
Compared with single-voxel H-MRS, multi-voxel H-MRS is advanced in detecting the spatial distribution of metabolic changes in brain lesions because of its successive feature.
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