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The findings, presented at the annual meeting of the Society for Neuroscience in San Diego, led researchers at McLean Hospital to surmise that the developing teenage brain may be particularly vulnerable to the ill effects of marijuana.
The adolescent brain may be particularly susceptible to the harmful effects of alcohol.
Thus, the alteration of gene expression in the brain may be particularly important for environmental adaptation.
Several studies suggest that the brain may be particularly vulnerable to oxidative stress [ 6- 9].
Concerns have been raised that the developing brain may be particularly vulnerable to adverse effects of neurotoxic pesticides.
The brain may be particularly sensitive to changes in temperature for two reasons: the brain is highly metabolically active; and, due to the rigid cranium, temperature-induced changes in metabolism and cerebral blood volume can result in changes in ICP.
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This suggests that gene expression in the brain and head may be particularly sensitive to DCC-induced upregulation.
Large brains may be particularly problematic for flying organisms because increased mass contributes substantially to the energetic costs of flight [ 8, 9].
Furthermore, our data nicely illustrate that evolutionary changes that drive species-specific patterns of gene expression in the developing brain are not a feature unique to the humans; the same sets of genes involved in brain patterning may be particularly prone to changes in transcriptional regulation in many mammal species.
This distribution has an antero-posterior gradient with a relatively reduced innervation of the posterior cerebral arterial circulation [13], and therefore, during acute elevation of blood pressure, posterior brain regions may be particularly susceptible to breakthrough of autoregulation.
In PrPC-deficient areas of the brain, Sho may be particularly important in filling-in a PrP-like activity.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com