Sentence examples for brain levels of soluble from inspiring English sources

Although the brain levels of soluble fatty acids have not been reported, fatty acids have long been known to be BBB permeable.

Brain levels of soluble Aβ oligomers play detrimental role in AD pathogenesis, by inducing neuronal dysfunction that have been shown to take place even before neurodegenerative cascades [ 4].

These striking differences in the brain levels of soluble Aβx-40 and Aβx-42 peptides, and the reversed ratio, between APP/E2 and APP/E4 mice are likely related to the well-established differential effect of apoE2 and apoE4 isoforms on Aβ brain clearance [ 28].

In contrast, the acute synaptic toxicity and very low brain levels of soluble Aβ oligomers suggest that anti-Aβ antibodies with selective affinity for soluble Aβ oligomers could provide therapeutic benefit for patients with mild cognitive impairment or mild-to-moderate AD.

Peripheral administration of a single chain antibody (scFv) to Aβ is as effective as intracranial administration of the scFv in reducing brain Aβ burden, but does not increase brain levels of soluble Aβ, which has potential to form more toxic oligomeric species [ 46].

At 12 months, the brain levels of total soluble and oligomeric amyloid-β were quantified (Supplementary Fig. 1B and C).

To further interrogate the possibility that HSJ1a may promote the rapid degradation of soluble mutant huntingtin in mouse brain lysates, we performed ex vivo degradation assays using 4-week old R6/2 brain lysates, which contain high levels of soluble mutant huntingtin.

Second, high levels of soluble Aβ40 in brain parenchyma, with up to a threefold increase, distinguish demented patients with AD from non-demented patients, even though the non-demented patients may have high numbers of insoluble Aβ plaques in their brains [ 62].

In the Tg2576 mouse line, deficits in spatial alternation (Y-maze) were noticed at seven months of age, before Aβ deposits were seen in the brain, but at a time when the levels of soluble Aβ 40/42 were already elevated [ 237].

Finally, levels of soluble Aβ in the brain could be reduced by acute treatment of ARTE10 mice with a γ-secretase inhibitor.

We have shown that brain homogenates from clinically affected voles contain low levels of soluble PrP (bona fide PrPC) (see Fig. 2).