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Therefore, our findings suggest persistent brain lesion rather than an acute or subacute lesion.
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Before 1950, according to David Armstrong, the medical gaze focused on the lesion, rather than the patient.
It helps that Ms. Johnson's brain damage was limited to discrete lesions rather than being diffuse or pervasive, the scientists say.
It is becoming increasingly clear that, as a rule, the aging brain is characterized by the simultaneous presence of multiple neuropathological lesions rather than the hallmark lesion(s) of a single age-associated neurodegenerative disease [ 1].
This confirms the current opinion that these disorders depend on the distribution of lesions rather than on their biochemical nature.
The presence of vitritis and gross macular oedema encourages calling them retinitis lesions rather than CWS.
Moreover, Shiozaki et al. reported that tiny lesions rather than larger lesions bled more frequently [ 25].
Thus, they expressed their findings as substantial FDG-PET/CT lesions rather than malignancies [ 8].
In other words, response heterogeneity was most prominent across lesions rather than across patients.
Our results suggest that tubulointerstitial lesions observed among patients with normoalbuminuria (normal proteinuria) and low eGFR are strongly affected by vascular lesions rather than by glomerular lesions.
To our knowledge, this study is the first to demonstrate that brain atrophy rather than cerebrovascular lesions may substantially mediate the relationship between T2DM and cognitive impairment, emphasizing the need to explore its underlying biological mechanisms.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com