The defect, which affects the brain, leads to excessive production of uric acid.
Their presence in the brain leads to neurodegeneration and memory decline.
The ensuing deposition of tau in the brain leads to dysfunction of brain cells and a loss of connections among them, ultimately causing them to die.
A goal of memory research is to understand how changing the weight of specific synapses in neural circuits in the brain leads to an appropriate learned behavioral response.
Finally, prediction of drug transport in the brain leads to improved treatment options for patients suffering from neurodegenerative disorders such as Parkinson's and Alzheimer's.
The present data suggest that the lack of dopamine D3 receptor genes in the mouse brain leads to the aggravation of the development of physical dependence on ethanol.
A decrease in the amount of blood that is supplied to the brain leads to light-headedness and loss of consciousness.
So it could be that this tussle between the genetic imperative and the brain leads to pain becoming so painful that, as it were, the hedonistic brain can't overrule".
Moreover, patients with Parkinson's disease have abnormally high iron levels in their brains but don't develop M.S., undercutting Zamboni's idea that an iron backup in the brain leads to the disease.
Based on a review of existing research, the researchers offer a new theory that an injury to the cerebellum during early life potentially disrupts this process and leads to what they call "developmental diaschisis," which is when a loss of function in one part of the brain leads to problems in another region.
Dementia with Lewy bodies (DLB) is the second most prevalent neurodegenerative dementia, where an accumulation of aggregated fibrillar alpha-synuclein in neurons of limbic and forebrain regions of the brain leads to visual hallucination, cognitive impairment of a fluctuating nature and extrapyramidal motor disturbances.
