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GT-tg mice with a doxycycline (Dox -inducible anDox -inducibleive tandgene coding for Tat protein were used to test the hypothesis that the activity of Tat in brain is sufficient to impair learning and memory processes.
First, we have included new data indicating that injury exclusively to the fly brain is sufficient to increase intestinal permeability.
We therefore asked whether selectively masculinizing fru+ LHNs in an otherwise female brain is sufficient to transform these neurons.
Activation of JNK signalling specifically in the insulin-secreting neurons (Dilp neurons) of the Drosophila brain is sufficient to confer an animal-wide resistance to stress and to extend lifespan via an inhibition of insulin secretion (42).
However, it still remains to be tested whether deletion of 11β-HSD1 solely in the brain is sufficient to recapitulate the HPA effects observed in a global knock-out on a 'HPA-dysfunction susceptible' strain background.
Neurite outgrowth starts at approx. E11 E12 (embryonic days 11 12) leaving 8 9 days until birth for outgrowth to proceed, allowing release-deficient neurons to attain a length of 5 10 mm which, given the dimensions of mouse neonatal brain, is sufficient to form long-distance connections.
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Indeed, the remaining Mena protein expression in the brain was sufficient to produce viable mice (MenaGT/GTVASP−/−).
The slight delay of complete inhibition of AChE in the blood and probably also in the brain by obidoxime might explain its therapeutic efficacy, as only little amounts of active AChE in the brain are sufficient to improve the aforementioned parameters (Bueters et al. 2003).
Also trigeminal inflammation inside the blood brain barrier is sufficient to elevate venous CGRP outflow [3], but there is discussion regarding the functional significance of resting as well as elevated blood CGRP levels.
Taken together, these experiments show that increasing Dilp expression, specifically dilp5 and dilp6, in brain IPCs is sufficient to ameliorate the lethality and delay phenotypes induced by developmental ethanol exposure.
Injection of pre-aggregated synthetic full length Tau and Tau fragments results in seeding and spreading of Tau-pathology in cells and in Tau transgenic mice, demonstrating that misfolded Tau per se, and not a different factor in the brain extracts, is sufficient to induce Tau-aggregation [ 35].
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com