Sentence examples for brain is primarily from inspiring English sources

In an in vivo pharmacokinetic analysis, brain accumulation of oral sorafenib increased in Bcrp1 −/− mice compared with wild-type mice, suggesting that its distribution to the brain is primarily restricted by BCRP [161]– [161].

This anatomical region of the brain is primarily responsible for sense of smell, and the potential ergogenic effects related to carnosine levels in the olfactory bulb are not well understood.

αSyn in brain is primarily localized to presynaptic terminals, and the vast majority of the protein appears cytosolic upon cellular fractionation, suggesting that associations with synaptic membranes are likely transient and/or weak.

The levels of these metabolites are determined by several KP enzymes, which in the brain are primarily contained in microglial cells and astrocytes (Fig. S1) [2].

ZEN neurons in the mammalian brain are primarily glutamatergic [8] [10] and forebrain regions such as hippocampus, amygdala and neocortex are crowded with ZEN terminals [11].

Gene expression analysis reveals that ErbB4 del.3 mRNAs in the fetal brain are primarily JM-b/CYT-2 isoforms with lower levels of JM-a/CYT-2, whereas those expressed in the adult are exclusively JM-a/CYT-2 isoforms, demonstrating that these splice isoforms are developmentally regulated.

In these sporadic cases the characteristic aggregates in the brain are primarily composed of misfolded, but wild type, disease proteins.

Although the immunoprecipitated APFs were morphologically similar to the synthetic peptides, they were not detected with Aβ and α-synuclein antibodies (4G8 and 4D6, respectively) by dot blot (data not shown), which suggests that APFs in DLB brain are primarily composed of tau protein.

Our brains are primarily visual.

Neuronal staining of CysC in AD brains was primarily limited to pyramidal neurons in cortical layers III and V, which are the neurons most susceptible to cell death in AD [53], [54].

In the brain, Iba1 is primarily expressed by microglia and its expression is upregulated upon microglial activation [ 69].