Located on chromosome 8, both are associated with cancer, and one, which is expressed in the brain, is implicated in epilepsy.
Abnormal development of the brain is implicated in the etiology and/or pathology of various psychiatric diseases, including schizophrenia [16], bipolar disorder [17], and depression [18], among others.
Protein aggregation leading to amyloid deposition in the brain is implicated in the pathology of a number of neurodegenerative diseases such as Parkinson's (PD), Alzheimer's (AD), prion diseases and others [1], [2], [3], [4].
Our functional study in cells with the 216Thr variant of ENT1 protein revealed that prolonged exposure to ethanol resulted in a statistically significant increase in the reuptake of adenosine (Figure 2), which might be a molecular basis of ethanol withdrawal seizures in humans because dysregulation of adenosine levels in the brain is implicated in seizures [13], [14], [15].
In VEEV infection, inflammation in brain is implicated in the secondary neuronal damage leading to morbidity and mortality.
See research article http://www.molecularneurodegeneration.com/content/7/1/48 The progressive accumulation of misfolded proteins in the brain is implicated in a vast group of human diseases, including the most prevalent neurodegenerative disorders such as Alzheimer's disease (AD), Parkinson's disease, and amyotrophic lateral sclerosis.
Dopamine and dopamine transporters (DAT, which regulate extracellular dopamine in the brain) are implicated in the modulation of attention but their specific roles are not well understood.
Our literature review finds evidence of age-related changes in human brain methylation and that aberrant alteration of brain methylation is implicated in AD.
Brain dopamine is implicated in the regulation of movement, attention, reward and learning and plays an important role in Parkinson's disease, schizophrenia and drug addiction.
Endogenous acj6 expression has been reported in the central complex of the brain, which is implicated in the coordination of locomotor behavior [22], reviewed in [25], but we did not detect acj6-GAL4 expressinn in this region.
UTS2, a neuropeptide expressed only in brain tissue, is implicated in regulation of sleep stages [ 29].
