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In contrast, a cohort of 77 patients with melanoma and brain involvement in which 35% of the patients received ipilimumab was reported by Knisely et al.
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Brain involvement in leukaemia can be direct (due to leukaemic infiltration) (Fig. 30) or indirect.
There are no specific diagnostic tests and treatment methods for brain dysfunction, and the exact mechanism of brain involvement in sepsis is not clear.
Our findings suggest that aCLs are associated with diffuse brain involvement in NPSLE patients.
Brain involvement in myotonic dystrophy types 1 and 2 has been demonstrated in vivo using different neuroimaging techniques.
These sites are also lesion sites in NMO patients with brain involvement [ 30, 43 ], which has initially been ascribed to the high AQP4 expression at these sites [ 31 ].
Brain involvement was present in 24% with HR+/HER2+ tumors and in 18% of patients with HR-/HER2+ tumors.
Spellberg and colleagues listed six groups of miscellaneous mucormycosis presentation in which they included brain involvement without sinus infection, endocarditis, pyelonephritis, bone infection, external otitis, etc. [ 53].
In addition to the heart, clinical/radiological signs of brain involvement were clearly present in several MTO1 mutant patients.
To exclude LARGE from genetic involvement in LGMD, or CMD with or without brain involvement it will be important to examine patients for genomic deletions in this gene.
Despite this, brain involvement is often an unrecognized complication in sepsis patients.
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