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Some of the patients had no amyloid in their brain, indicating that the vaccine removed amyloid as expected.
Distribution assay of PLGA nanoparticles in different tissues like brain, heart, kidneys, liver, lungs, and spleen in mice revealed the presence of nanoparticles in different tissues including brain, indicating that the particles could cross the blood brain barrier, significant information for drug design.
Furthermore, we demonstrated that there were no gender differences in BACE1 activity in aged brain, indicating that the increased in vitro γ-secretase activity in female mice at 24 months would likely be translated into increased Aβ production in vivo.
In Mcph1gt/gt the mRNA level of wt Mcph1 was reduced to approximately 9%±2.5 in spleen, 19% ±3.2in liver, and 28% ±4.3in brain, indicating that the Mcph1 genetrap mutation results - as expected - in a preferential splicing of exon 11 of the Mcph1-gene to the gene trap vector.
FoxP2 hum mice also showed reduced dopamine concentrations in the brain, indicating that the humanized FoxP2 allele affects the basal ganglia.
The analyses found no evidence of albumin in the brain, indicating that the BBB had remained intact following the ethanol treatment.
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It was reported that unmodified Aβ1-40 and Aβ1-42 can be modified into AβpE3 after being injected into rat brain indicating that rat brains harbor the enzymes required for N-terminal truncation and pyroglutamate formation [ 63].
In contrast, quantification of sarkosyl-insoluble tau in the brain indicated that trehalose decreased the amount of insoluble tau compared with untreated controls (−53%, P < 0.01) or to controls treated with sucrose (−46%, P < 0.05) (Fig. 2A).
18F-TCO enters the brain indicating that this tracer could also internalize cells, but unfortunately, it was quickly metabolized in vivo precluding its use for pretargeting.
All of them were also expressed in the adult brain, indicating that these gene products may have a functional role in both adult and embryonic brains.
The organization of the thermosensory system in the brain indicates that the discriminative thermosensory capacity of humans has evolved as one aspect of the enormous encephalization that has produced a direct sense of the physiological condition of the body.
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