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This in turn is reflected by the more non-neuronally specific transcriptome patterns seen in samples derived from the total brain in this study.
There is an abundance of NSCs in the fetal brain, in this study we will use the term neural stem cells to refer to all classes of immature and proliferating cells that reacted with CD133 and nestin.
In order to compare our human tissue to well-fixed material, we included a monkey brain in this study.
D-REAM analysis was performed twice for each of the biological duplicates of heart, and once for the liver and brain in this study.
Although lipid metabolism was not studied in the brain in this study, we postulate that the disturbances in lipid metabolism might affect the assembly of the myelin sheath, leading to defective myelination.
Given the progressive degenerative nature of MSD, it is unclear whether there are similar mitophagy defects in the brain that may have been masked by the nature of the experimental material (whole brain) in this study.
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"We looked at human brains in this study, too, and we found that a similar derangement of cofilin activity is present in Alzheimer's brains but not healthy brains," she said.
Because many aging brains have comorbid pathologies, the numbers of pure AD, LBD, and AGD brains in this study were relatively small.
As Casp6 is predominantly activated in sporadic and familial AD brains, in this study, we investigated if APP wild-type or familial AD-associated APP mutants induced Casp6 activity.
Although it is generally considered that trastuzumab poorly penetrates the blood-brain barrier (BBB), we were able to visualize brain lesions in this study.
Owing to the investigation of two separate brain regions in this study, we used a volume divided by total brain volume account to provide the relative contribution of both structures to memory performances.
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