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Dr. Leonard was still a graduate student when he began his studies of sex hormones, produced at the base of the brain in the pituitary gland.
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It is a small cone-shaped structure that projects downward from the brain, ending in the pituitary (infundibular) stalk, a tubular connection to the pituitary gland.
A doctor in the audience had picked up the unmistakable signs of acromegaly: the swollen, elongated nose and jaw that result when a benign brain tumor in the pituitary gland overproduces growth hormone.
Relative to other tissues, the Novartis gene expression atlas (SymAtlas) shows BLCAP mRNA levels to be high in brain, the pituitary and the immune system (5) (Affymetrix probe set 201032_at).
Blcap mRNA levels are relatively high in brain and the pituitary, but not the immune system (SymAtlas probe set gnf1m03525_a_at).
The D2-like receptor group is also expressed centrally in many areas of the brain and peripherally in the pituitary, blood vessels, the heart, the adrenal gland, and the kidneys [ 1, 4, 15, 17].
The IR-MEAP levels in the brain and the pituitary gland are shown in Table 1.
The IR-N/OFQ levels in the brain and the pituitary gland are shown in Table 1.
This can occur for example after a surgery to the brain in the region near the pituitary gland which can affect this gland also.
In addition to the POMC neurons in the brain, the pituitary contains large numbers of POMC-producing cells.
It should be also noted that the morphology of congenital disorders of the brain acquired anatomical features of the brain tissue and changes in the pituitary gland are rare finds and occur in isolated cases.
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