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Our results thus suggest that different selective forces influence the evolution of the distinct structures within the brain, in line with the mosaic model of brain evolution [8], [21], [22], [23].
Interestingly, we found MAP1B less phosphorylated in MDD brain, in line with previous functional studies which suggested that a dephosphorylated state of MAP1B may trigger cytoskeletal alterations that will impair long-term potentiation leading ultimately to impaired synaptic plasticity [ 62].
These albeit inconsistent findings do suggest an adverse impact of type 1 diabetes on the developing brain, in line with evidence for neurocognitive deficits in childhood-onset type 1 diabetes (6).
At visual inspection, it seems that more cells are generated and integrated into the cerebellum than in any other region of the N. furzeri brain, in line with the extensive cerebellar neurogenesis reported in other fish species (Zupanc & Horschke, 1995; Ekstrom et al., 2001; Adolf et al., 2006; Kaslin et al., 2009; Kuroyanagi et al., 2010).
In contrast, we found no detectable CAR immunopositivity within the brain, in line with previous studies showing the white matter being CAR-negative and scattered CAR-positive neurons within the neocortex and in ependymal cells only (Johansson et al, 1999; Persson et al, 2006).
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A similar mechanism could take place in human Alzheimer's disease and variant CJD, as our results could be interpreted as increased neurogenic activity at the dentate gyrus in these diseased human brains, in line with previously reported data (Jin et al., 2004).
Also tetraodon displayed P lineage expression in the brain (SRA dataset SRX191169) suggesting P genes have a biological role in teleost brain potentially in line with the roles emerging for mammalian classical as well as non-classical MHCI molecules in brain development and function [ 79- 81].
The higher γ-secretase activity in membranes from embryonic rat brain is in line with the reported higher levels of transition state γ-secretase inhibitor binding in postnatal rat brain compared to adult [41].
A month later, following a second post-mortem examination by another pathologist, he prepared an addendum to his report changing the cause of death to a brain haemorrhage in line with the new findings.
Most of these studies showed a nicotine driven facilitation of brain processing in line with our findings [19 22].
They were absent from fetal brain cells, in line with them being erythroid-specific hypersensitive sites (Figure 6D).
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