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Here we test this hypothesis in a mouse model by assessing the chemotherapeutic activity of p97-drug conjugates within the brain in comparison with unconjugated drugs.
We determined the pharmacokinetics of FGF19 permeation from blood to brain in comparison with its distribution in peripheral organs.
Figure 2c indicates that neuronal cells may be damaged in HFD brain in comparison with the normal brain.
However, a close structural analogue, retigabine, has been found to achieve sixfold higher concentrations in the brain in comparison with plasma (Sotty et al., 2009).
This observations agree with those studies in which very low levels of GAP-43 mRNA were found in cortical neurons of postmortem AD brain in comparison with control slices, as wells as in APP-transgenic mice.
Interestingly, treatment was found to protect the animals from experimental cerebral malaria, with a reduction in the accumulation of parasites in the vasculature and brain in comparison with control animals.
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During Loo's stay in the Western Reserve University, Cleveland, Ohio, United States, he observed and collected statistical data on fifty Chinese brains in comparison with fifty Negro and fifty White.
Western blot analysis of PrPres from H-type infected mouse brains in comparison witH-type infectedmouseis shown in Figure 1.
To retrieve genes whose expression levels were significantly altered in AD brains in comparison with non-AD brains, it is essential to consider the changes in the population of brain cells in AD brains.
Expression of chemokines and their receptors is dysregulated in HIV and simian immunodeficiency virus encephalitic brains in comparison with normal brains, as well as microglia/ macrophages, astrocytes, endothelial cells, and neurons exposed to HIV or soluble viral proteins.
By WB, we observed a modest but significant accumulation of RTP801 in 8-month-old PaKO mouse brains in comparison with wild-type littermates, confirming in vivo that parkin loss results in elevated RTP801 protein.
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