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Some patients have brain imaging abnormalities, such as focal infarction, brain malformations and periventricular leukomalacia; however, not all children with cerebral palsy have abnormal brain imaging and determining the aetiology in such cases is particularly challenging (O'Shea, 2008; Reid et al., 2013).
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However, almost all of these patients had laboratory derangements such as hypomagnesemia or renal insufficiency, or imaging abnormalities such as brain metastases, which could lower the seizure threshold.
Case 5 had no brain imaging abnormalities and most closely resembles the other cases in our series.
How these brain-imaging abnormalities evolve over time is unknown.
Relatively few studies have specifically examined metabolic and vascular determinants of brain-imaging abnormalities in patients with type 2 diabetes.
Brain images provide signals of brain anatomy and can be useful in diagnosis of numerous brain abnormalities such as malignant glioma [1].
Further research into this potential link between intracranial vascular anomalies and brain abnormalities, such as with noninvasive MR angiography and perfusion MR imaging, may be of value.
Subtle brain abnormalities such as broadened lateral ventricles were seen on MRI in some patients.
Brain imaging did show abnormalities in the central white matter, suggesting delayed or abnormal myelination.
Patients should thus be carefully monitored with brain imaging for amyloid-related imaging abnormalities and any associated clinical features [ 56].
And, they hope to discover how and where in the brain Ptchd1 mutations produce other abnormalities, such as aggression.
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