In the rat brain, high densities of α7 nAChRs are found in the hippocampus, hypothalamus, and cortical areas, whereas they are expressed to lesser degrees in the striatum and cerebellum [5].
In support of this hypothesis, LCAT has recently been shown to be expressed by astrocytes and to play a critical role in the maturation of brain high-density lipoproteins and cholesterol distribution [ 25].
In rats, VOIs were drawn in four adjacent transaxial planes over frontal cortex, a region in the rat brain with high density of GABAA receptors.
According to the literature, A1R is abundant in most regions of the brain, with high densities in the hippocampal area, cerebellum and cortex, and A2AR has high densities in the basal ganglia, nucleus accumbens and olfactory tubercle [ 42].
The other included brain regions with high density of CB1 receptors, for instance hippocampus, did not differ between these groups.
The primary advantage is that there is an increase in resolution of cell bodies and processes in regions of the brain containing a high density of FTL positive neurons, in particular in cortex (9) (Fig. 1C, D shows amygdala region).
In the rainbow trout brain, the highest density of GRP-like immunoreactivity is observed in the hypothalamic area were positive cell bodies were detected.
In the brain, the highest density of TPSO reported is in the olfactory bulbs [ 4]; this correlates with the results obtained with [I]-CLINDE [ 43] and other radiolabelled radiotracers belonging to the N-benzyl N- 2-phenoxyaryl -acetamide series (DAA tracers) [ 44, 45].
The distribution of MLA, a non-diterpenoid alkaloid, binding sites in rat brain has been reported: high density in hippocampus and hypothalamus, low density in striatum and cerebellum [ 16].
Therefore the very high TDFNB regions are most likely contributed by the high level expression of brain-enriched gene clusters or the regions containing a high density of brain-enriched genes.
We present a proof of concept study in patients with acute brain injury in the intensive care setting, featuring a bedside functional imaging set-up designed to map cortical brain activation patterns by combining high density EEG recordings, multi-modal sensory stimulation (auditory, visual, and somatosensory), and EEG source modeling.
