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No increases in the frequency of amyloid plaques in the brain have been found in dialysis patients or in aluminum workers, both groups of people with extensive contact with aluminum.
In addition, changes in gamma oscillatory activity in human brain have been found in several psychiatric illnesses including schizophrenia and bipolar disorder [14], [15].
Evidence that the MedDiet may reduce the risk of unsafe levels of these biological markers in the brain have been found in a number of recent studies.
In a study by Fan et al. (2007), many O4+ OLs in the rat brain have been found double labelled with 4-HNE and malondialdehyde.
In primary mood and anxiety disorders, no structural pathological changes in the brain have been found, although abnormalities of neurotransmitter function have been postulated [ 85] and are consistent with the observed effects of some treatments [ 86].
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There may be biological reasons behind women's tendency to brood, but no genetic predisposition or difference in the brain has been found.
Intravenous CCK, a naturally occurring neuropeptide in the brain, has been found to induce the emotional and somatic symptoms of panic in both Panic Disorder (PD) and Normal Control (NC) subjects in a dose-dependent and reproducible fashion.
While genetic deletion of EphBs from mouse brain has been found to result in fewer dendritic spines [16] and excitatory synapses [22], less is known regarding how reduced EphB expression in individual neurons in a more intact preparation impacts dendritic protrusion length.
The brain has been found to be the main source of BDNF concentrations in venous blood (circulating BDNF) [ 44].
Recently, chronic Tat exposure in the brain has been found to decrease locomotor activity and the amplitude of its circadian rhythm in Tat transgenic mice [ 11].
Mitochondrial damage similar to that found in the aging brain has been found in the PD brain where the accumulation of mtDNA mutations is usually higher in patients over 65 years of age (Kraytsberg et al., 2006).
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