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Indeed, an environment-dependent requirement for p38 MAPK in the brain has been observed in knockout mouse strains reared under different environmental conditions [52].
Extensive heterogeneity of NFAR proteins in mammalian brain has been observed before [25] and may be due to splice variation [25] and post-translational modifications, e.g., arginine methylation [26], lysine acetylation [27] or phosphorylation [8].
During normal ageing, increased SNCA expression in the brain has been observed in both healthy humans and monkeys [ 42].
Reduced MeCP2 expression in brain has been observed in 79% of autism cortex samples (16) and functional variants of the MECP2 gene may confer autism vulnerability (17).
Stochastic resonance in the brain has been observed from the operations of single neurons to intercellular communication and perceptual and cognitive phenomena.
Interestingly, increased expression and/or transcriptional activity in HD model mouse brain has been observed for other transcription factors reported to be affected by mutant huntingtin.
Similar(53)
Dendritic proliferation and sprouting in human AD brain have been observed by Golgi impregnation[30] and by MAP2 and tau immunohistochemistry highlighting growth cones present both in perisomatic dendrites and in distal, dystrophic neurites[20].
More specifically, abnormalities in brain regions such as the amygdala, hippocampus, and frontal cortex; decreased cortical thickness; axonal degradation; and decreased functional connectivity in the brain have been observed.
Furthermore, alterations in brain volumes [19], [37], [38] and abnormal axonal connectivity, in particular within the corpus callosum (the highest myelinated fiber tract in the brain), have been observed in children with a history of abuse or neglect [3], [39], [40], [41], [42].
For animals inoculated with classical scrapie isolates (groups 2 and 3) or experimental TSE sources (groups 4 and 5), negative PrPres/PrPsc brains have been observed, but only in [TgOvPrP4 (x0.25)] mice (9/14) or very rarely in [TgOvPrP4 (x1.5)] mice (1/97), whereas all the 58 mice from the other group were PrPres/PrPsc positive (Figure 2A).
Indeed, no apparent brain damage has been observed in ADHD brains.
More suggestions(15)
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