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Oligodendrocyte damage resulting in periventicular leukomalacia (PVL) in the developing brain has been implicated.
Enhanced mammalian target of rapamycin (mTOR) signaling in the brain has been implicated in the pathogenesis of autism spectrum disorder (ASD).
An abnormal accumulation of extracellular K+ in the brain has been implicated in the generation of seizures in patients with mesial temporal lobe epilepsy (MTLE) and hippocampal sclerosis.
The alpha-7 nicotinic acetylcholine receptor (α7-nAChR) is well known as a potent calcium ionophore that, in the brain, has been implicated in excitotoxicity and hence in the underlying mechanisms of neurodegenerative disorders such as Alzheimer's disease.
Activity of AQP4, the predominant aquaporin in the brain, has been implicated in brain edema.
The aggregation of αS in the brain has been implicated as a crucial step in the formation of Lewy bodies and curcumin has antifibrillogenic and fibril-destabilizing properties, thus inhibiting the formation of alpha synuclein fibrils [ 37, 38].
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Low GABA levels in the brain have been implicated in epilepsy and several other neurological diseases.
Genetic defects in neurochemical messenger systems in the brain have been implicated in panic.
Although the precise cause of PDD-NOS is unknown, abnormalities in certain structures and in neuronal signaling pathways in the brain have been implicated.
Astrocytes, the major non-neuronal cells in the brain, have been implicated in providing tropic support for the neurons.
Dysregulations in the serotonergic system in the brain have been implicated in a variety of psychiatric disorders, such as depression, suicide, schizophrenia and addiction, which are accompanied by abnormal amygdala function [5].
More suggestions(17)
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Justyna Jupowicz-Kozak
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