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The brain harbours a large variety of neuron types and sub-types, besides a large number of glial cells.
With the implantation during this last decade of the NS forming assay as a robust method for the isolation of neural stem cells [ 18], it has become widely accepted that adult mammalian brain harbours a pool of NSCs responsible for the persistent neurogenesis, seen in limited adult brain regions, such as the sub-ventricular zone, olfactory bulb and hippocampal dentate gyrus [ 19].
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Are we the sum total of our vital organs or does our brain harbour some extra element that gives us an identity?
Whether brains harbouring malformations are more vulnerable to superimposed neurodegenerative processes has been little explored.
Post-mortem studies of brains harbouring high levels of mtDNA deletions (due to point mutations in the nuclear encoded mitochondrial DNA polymerase, POLG) demonstrate that such deletions are indeed associated with complex I deficiency, but that this is not necessarily correlated with parkinsonism (Palin et al., 2013).
This study was one of the first to show that extra-SCN brain regions harbour an autonomous circadian oscillator.
Moreover, in a pilot study [28] of 24 symptomatic, very advanced melanoma patients with brain metastasis and harbouring a BRAF V600 mutation were treated safely and effectively with vemurafenib, improving patients' performance status and quality of life.
We have characterised a new imprinted cluster on human chromosome 8q24, which harbours two brain-specific genes.
The authors identified 66 loci that harbour potential brain tumour-associated oncogenes that collaborate with PDGF-β.
As expected, hemichannel activity, as demonstrated by EtBr uptake, was significantly elevated in brain slices from WT animals harbouring brain abscesses.
The strongest evidence for transcriptional dysregulation comes from the observed interaction between the glutamine rich regions of Sp1 with Huntingtin protein harbouring polyglutamine expansion in brain tissue from Huntington patients [11].
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com