Consistent with our assumptions, the present findings are partly different from what we have found in our prior study for PBD-mania [ 15], suggesting that there could be different brain functional alterations involving in different mood episodes.
More importantly, the brain functional alterations induced by training were found in the fusiform gyrus for both tasks.
Furthermore, we found that amount of rabies virus in the brain should not be the sole contributing factor in determining the functional degree of brain functional alterations.
We aimed to provide additional evidence that brain functional alterations induced by IBS are not limited to local changes but also express at a level of functional integration within related brain regions involved in processing of visceral afferent information and somatic pain.
Several fMRI studies in migraine assessed resting state functional connectivity in different networks suggesting that this neurological condition was associated with brain functional alteration.
Repeated epileptic seizures can result in neuronal cell loss, persistent neuro-inflammation, disturbance of blood-brain barrier function, and functional alterations in neurotransmitter receptors and ion channels [ 3– 5].
Our previous fMRI study demonstrated that some brain regions are functional alterations in migraineurs.
Typically, brain insults produce morphological and functional alterations in the hippocampal formation, including neurodegeneration in CA1, CA3, and, most consistently, the dentate hilus.
Research in mice has shown that altered 5-HT availability during a critical window of early development, through genetic or pharmacological manipulations and/or environmental events, can result in structural and/or functional alterations in brain neurotransmission with deleterious consequences on emotion regulation in adulthood [37], [38].
There are many reports on brain region specific structural and functional alterations in PTSD patients and PTSD animal models.
