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The central hypothesis examined in this issue is that insulin resistance promotes maladaptive brain function and contributes to reduced neuronal plasticity, potentially accelerating brain aging.
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For the same reason, chronic impairments of neuronal metabolism would be expected to compromise brain function and contribute to brain pathology, which may be the case in epilepsy (due to runaway excitatory activity or directly to metabolic disorders [57]), sepsis [58], mitochondrial disorders, which strongly affect the brain [59], and Alzheimer's disease [60].
These sequences are not heritable but can cause mutations which interfere with brain functions and can contribute to the development of psychiatric disorders [ 9].
Although scientists once believed that the adult brain could only lose neurons, research over the past several years has shown not only that new neurons form regularly a process called adult neurogenesis but also that they contribute to brain function and are diminished in certain diseases and disorders.
However, this silencing property could be useful in experiments that investigate situations in which depolarization block is thought to contribute to brain function and health: such as in the treatments of schizophrenia and Parkinson's disease.
These are considered oily fish with high levels of omega-3 fatty acids that contribute to healthy brain function and reducing memory loss.
Integrating these methodological approaches offers novel opportunities to identify mechanisms through which serotonin signalling contributes to differences in brain function and behaviour, which in turn can illuminate factors that confer risk for illness and inform the development of more effective treatment strategies.
Dopamine (DA) is a neurotransmitter that contributes significantly to normal brain function and is implicated in multiple neurological and psychiatric disorders.
Therefore, certain diets might improve brain function and, for example, it has been shown that dietary lipids contribute to the function of the brain [ 66].
It is thought that a proper balance between excitation and inhibition is essential for proper brain function, and that an imbalance in the number of excitatory pyramidal neurons and inhibitory interneurons could contribute to conditions such as autism and epilepsy.
However, if the lateralization of brain functions does indeed contribute to our findings, hemispheric asymmetries in global and local processing may influence brain function and behavior to a higher degree than has so far been recognized.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com