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Cellular signaling networks play an essential role in brain function and are commonly mediated by protein phosphorylation.
Although scientists once believed that the adult brain could only lose neurons, research over the past several years has shown not only that new neurons form regularly a process called adult neurogenesis but also that they contribute to brain function and are diminished in certain diseases and disorders.
Glia are integral for normal brain function and are found throughout the brain under normal conditions.
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However, pathological, excessive synchronization may strongly impair brain function and is a hallmark of several neurological disorders.
The nicotinic acetylcholine receptor α4β2 is important for normal mammalian brain function and is known to express in two different stoichiometries, (α4 2 β2)3 and (α4 3 β2)2.
This interferon signature had a negative effect on brain function, and was induced by brain-derived signals derived from the CSF.
Dopamine (DA) is a neurotransmitter that contributes significantly to normal brain function and is implicated in multiple neurological and psychiatric disorders.
This structural connectivity is a major determinant of brain function and is frequently used by neuroscientists and clinicians to interpret physiological data.
The cerebrospinal fluid, its composition, circulation and absorption, has multiple roles in both normal and abnormal brain function and is closely associated with the neuronal interstitial fluid.
Systemic inflammation impairs brain function and is increasingly implicated in the etiology of common mental illnesses, particularly depression and Alzheimer's disease.
The BBB plays a pivotal role in supporting proper brain function and is modulated by signaling inputs of surrounding ACs and PCs to maintain its unique properties and function [ 3, 5, 19].
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