Sentence examples for brain from the peripheral from inspiring English sources

The BBB protects the brain from the peripheral circulation and toxic substances and restricts the transport of many therapeutically important drugs from the blood into the brain.

New focal white matter lesions appear to develop following new waves of inflammation, involving immune cells which enter the brain from the peripheral blood and cause major blood brain barrier (BBB) leakage mediated by matrix metallproteinases (MMP).

Although cyclodextrin does not cross the blood-brain barrier efficiently, small amounts of cyclodextrin can enter the brain from the peripheral circulation.

The modest increases that were observed in 11β-HSD1−/− mice hippocampus during the dark phase probably reflect the ∼5% of free CORT (i.e. not bound to CBG) entering the brain from the peripheral evening rise in CORT.

Furthermore, it protects the brain from the peripheral circulation and toxic substances and restricts the transport of many therapeutically important drugs from the blood into the brain, including Alzheimer drugs, anticancer drugs, antibiotics and a wide variety of CNS-active drugs [ 22- 24].

This helps separate the therapeutic effect of MSF in the brain from the undesired peripheral cholinergic side effects that are commonly experienced with the currently available short-acting AChEIs which also may limit dosing to what can be tolerated by the patients.

Post hoc analyses showed that percent AChE inhibition in the brain was different from the peripheral tissues (P < 0.01) but there was no difference between peripheral tissues.

Conversely, intrinsic brain expression of Cyp27a1 might enhance the egress of cholesterol, released from damaged cell membranes, from the brain to the peripheral circulation.

This raised the possibility that P-gp might play a role, as it is inducible and its localization at the BBB has been shown to strongly limit the brain accumulation of drug substrates by transporting them from the brain into the peripheral blood supply (Boulton et al, 2002; Doran et al, 2005; Linnet and Ejsing, 2008).

The course within the brain is known as the central course of the nerve, and the course after it has emerged from the brain as the peripheral course.

Many different cell types from the brain and the peripheral tissues produce these peptides.