Mechanics are increasingly recognized to play an important role in modulating brain form and function.
This relationship is clinically important since modern imaging techniques reveal a close correlation between brain form and function (Raybaud and Widjaja 2011).
Therefore, the advent of RNA based networks is thought to be responsible for fueling the explosive evolutionary innovations, which may characterize the human brain form and function [ 41, 78, 79].
Here, we show that classical mechanical concepts including deformations, stretch, strain, strain rate, pressure, and stress play a crucial role in modulating both brain form and brain function.
In order to determine which zebrafish 16p11.2 homologs were active as the brain formed and began to function, we screened these for activity during brain development, from 24 hpf through 5 days post-fertilization (dpf), the human developmental equivalent of 5 weeks of gestation to toddlerhood.
The skull exhibits distinctly developed upper and lower temporal fenestrae (that is, openings behind the eye sockets); the teeth arise from sockets, and the roof of the skull lacks an opening for the parietal organ a median, dorsal outgrowth of the brain (see tuatara: Form and function).
The MB may therefore represent an evolutionary primitive brain structure homologous in form and function to structures in the vertebrate brain (Schurmann, 1974; Laurent, 2002; Tomer et al., 2010; Farris, 2011).
Kaufer's team is examining how early trauma might set the fate of white matter, and ultimately the form and function of the developing brain.
In axons, eAβOs impair transport of cargoes such as mitochondria and vesicles containing brain-derived neurotrophic factor (BDNF) [ 9– 11], which are both required for neuronal form and function.
Both form and function have been impaired.
The debate essentially surrounds form and function.
