Sentence examples for brain exposure from inspiring English sources

The in vivo results showed that liposomal formulations provided enhanced brain exposure.

This increased antitussive potency probably resulted from the improved brain exposure of compound 1b.

However, the advances in using antibodies directed at brain targets have also demonstrated impediments of low brain exposure in achieving clinical benefits, spurring increased attention in technologies designed to improve brain exposure of antibodies.

Several issues of the initial lead structures had to be resolved, such as potency, selectivity over related GPCRs and P-gp efflux limiting brain exposure in this series.

Moreover, this compound had proper lipophilicity (logD=2.78) and good solubility in water (>10 mg/mL), and exhibited good plasma and brain exposure when given orally.

However, the blood-brain barrier (BBB) limits the brain exposure of biologics and the chemical space for small molecules to be BBB permeable.

Such differences may affect brain exposures and both efficacy and adverse event occurrence.

The percent Aβ42 lowering of each dosed animal was plotted against the plasma and brain exposures in μM.

In the 15 mg/kg BID-treated animals, brain exposures of 3.6 ± 0.1 μM and a plasma exposure of 3.4 ± 0.2 μM to reduce brain Aβ42 by 22%.

The 30 mg/kg dose lowered both Aβ38 and Aβ42 levels in the brain by roughly 44%, with brain exposures of 16 ± 1 μM and plasma levels 13 ± 1 μM, once again without significantly affecting Aβ40.

We used PFC levels measured in maternal blood early in pregnancy as the measure of fetal exposure, but it is not clear to what extent these measures reflect critical fetal brain exposures throughout pregnancy and in early childhood.