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The brain entry of risperidone and 9-hydroxyrisperidone is greatly limited by P-glycoprotein.
Bacskai, B. et al. Four-dimensional multiphoton imaging of brain entry, amyloid binding and clearance of an amyloid-β ligand in transgenic mice.
Candidate radiotracers can fail as a result of poor passive brain entry, rejection from brain by efflux transporters or undesirable metabolism.
The results showed: (1) the effectiveness of using microemulsions as precursors to engineer nanoparticles, (2) kinetic modeling for brain uptake of nanoparticles with and without the thiamine surface ligands, and (3) initial data suggesting mechanisms for nanoparticle brain entry.
The more lipophilic molecule is undesirable not only for slowing passive brain entry but also for increasing high non-specific binding to brain fats and protein.
Nevertheless, it has fared better than Brannian's Lizard Brain entry, which crashed, dislodged its motor and lost 10 laps as Brannian made makeshift repairs.
Similar(39)
I mean at this point 1/3 of humanity is online, so there are a lot more ways to win then to start sketching out individual data packets (I'm a huge fan of that USB brain piercing entry below).
Vegetative bacteria are then released from the phagocytes, enter the bloodstream [2] and proliferate in long chains at preferred sites like the brain, allowing entry into the central nervous system (CNS) and development of anthrax meningitis.
For some time now, Pirsig's magnum opus has been knocking at the back door to my brain and demanding entry, so I just answered the call.
Professor Rothman discovered key molecular machinery responsible for transfer of materials among compartments within cells, providing the conceptual framework for understanding such diverse and important processes as the release of insulin into the blood, communication between nerve cells in the brain, and the entry of viruses to infect cells.
The first one refers to Eccles' intention to utilize quantum processes in the brain as an entry point for mental causation.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com