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To determine where in the brain enhanced production of APP was occurring, we performed fluorescent immunohistochemistry for APP on sections of brain from wild-type mice 4 days after infection with C. albicans using an antibody that only recognizes APP and not Aβ.
We found that these mice display abnormal synapse organization and maturation in vitro, altered synapse density in the adult brain, enhanced glutamatergic transmission and reduced synaptic plasticity in CA1 hippocampus.
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He speculated that because chewing increased heart rate, it would increase oxygen supply to the brain, enhancing cognition.
In other words, East Asians and Africans probably have other brain enhancing alleles, not yet discovered, that have spread to high frequency in their populations.
"I have a theory," he said, telling me he believes that music training at an early age -- when there are more neurons in the brain -- enhances the band of fibers that connects the two hemispheres of the brain.
It seems probable therefore that Pb2+ accumulation in the brain enhances TRPC5 activity in the amygdala, raising sensation of fear.
The GABA-benzodiazepine complex hypothesis suggests that benzodiazepines attach to GABA-benzodiazepine complexes in the brain, enhancing chloride conduction resulting in the release of GABA.
Given the complications associated with administering NMDA (N-methyl d-aspartate) receptor antagonists to the developing brain, enhancing astrocytic glutamate detoxification may represent a novel alternative means of providing neuroprotection after a developmental brain injury (Ikonomidou et al., 1999).
An evolutionary arms race drove the search for bigger and better brains, enhanced senses and faster motor coordination and responses.
"Once we are aware of it, our brains enhance it.
Many biohackers are now choosing to take brain enhancing substances -- or "nootropics" -- that supposedly allow you to tailor your brain to fit your needs, rather than letting your brain control you.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com