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It seems therefore that the mutant C allele of GSK-3β gene polymorphism may not only be connected with a better clinical lithium response due to the brain effect of this drug, but that also it is protective against the lithium effect on some aspect of kidney function.
Can we extrapolate that to a protective brain effect in living humans quite yet?
T-contrast whole brain effect maps showing neuroanatomical associations between performance on Tasks 3 4 and grey matter volume in the PCA group are displayed in Fig. 6.
Future studies might usefully start with 10 min zero-order infusions to clearly define the hysteresis between arterial concentrations and brain effect and then move to shorter infusions to replicate clinical practise at induction and longer fixed rate infusions before attempting TCI.
The location of the maximal association within this region lies at the boundary of the pre-specified occipital region; this, along with associations shown in the whole brain effect maps, suggest the critical region is not confined to the occipital lobe but extends into the temporal cortices.
Additionally, when meta-analyzing the available foci according to the class of antipsychotics or type of study design in relation to the resultant brain effect (i.e., volumetric excesses, volumetric decreases), excessive fragmentation of the data prevented the findings of significant foci of convergence with typicals.
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Salimpoor responds that previous research showed similar brain effects using only instrumental music.
This study shows that ITH12118 could be a paradigmatic multitarget compound having selective brain effects with smaller peripheral side effects.
They have brain effects, but the brain effects vary across classes of individuals in ways that depend on other environmental and genetic contexts (see Kendler and Prescott 2006 for a comprehensive review).
It is also a "neurosteroid" and possesses intrinsic behavioral and brain effects in animals, affecting the GABAA and other receptors.
About twenty studies have been published on brain effects of psychological treatments for obsessive compulsive disorder, anxiety disorder (e.g. panic disorder and social phobia), schizophrenia and depression.
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