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It is well-known that a primary brain dysfunction leads to episodic activation and sensitization of the trigeminovascular pain pathway during attacks.
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Brain mitochondrial dysfunction leads to imbalance of aerobic and anaerobic metabolism and triggered various cellular responses, including tau protein phosphorylation and cell cycle re-entry.
The mechanism by which global metabolic dysfunction leads to focal brain injury in metabolic stroke is not well understood.
This will provide insight into synapse function, and understanding of how synaptic complex dysfunction leads to various brain disorders.
In particular, gut barrier dysfunction leads to bacterial invasion and excessive inflammation35,36.
How antiquitin dysfunction leads to cerebral dysgenesis is unknown.
Migraine arises from a primary brain dysfunction that leads to episodic activation and sensitization of the trigeminovascular pain pathway.
However, the mechanisms of brain dysfunction that lead to these primary headache disorders, and more specifically to activation of the trigeminovascular pain pathway, remain largely unknown.
The ensuing deposition of tau in the brain leads to dysfunction of brain cells and a loss of connections among them, ultimately causing them to die.
However, there may also be 'true' variability in the underlying neurobiology of obsessive compulsive disorder, that is, it may be that dysfunction of different brain regions leads to highly comparable changes at the behavioural level, because these regions are part of the same brain network involved in the regulation of anxiety and safety behaviours.
It appears as if glucose regulatory dysfunction often leads to heightened dysfunction subsequent to stress.
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CEO of Professional Science Editing for Scientists @ prosciediting.com