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Acute brain dysfunction is a common complication of sepsis, which has been reported to be associated with adverse outcomes like long-term cognitive impairments.
Brain dysfunction is a serious complication of sepsis.
On one side, brain dysfunction is a poorly explored complication of sepsis.
Brain dysfunction is a frequent complication of the critically ill patients.
Delirium, a form of acute brain dysfunction, is a leading cause of morbidity and mortality in critically ill patients [ 1- 6].
Brain dysfunction is a frequent and severe complication of septic shock, as it occurs in up to 60% of patients [ 1, 2] and is associated with increased mortality [ 3] and long-term cognitive impairment [ 4, 5].
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Thus, the search for biomarkers of brain dysfunction is an important field in critical care research.
Once brain dysfunction is identified, an exhaustive neurological examination assessing neck stiffness, motor responses, muscular strength, plantar and deep tendon reflexes and cranial nerves is mandatory.
HIV-associated brain dysfunction is potentiated by a cascade of excitotoxic and apoptotic processes that amplify immunologic and inflammatory responses to the virus [ 87, 96, 99].
A slight interictal brain dysfunction is probably present between attacks.
With regard to acute brain dysfunction, is the delirium-to-coma transition merely a continuum of progressively lesser degrees of arousal, or is there a fundamental change in the pathophysiology of the acute brain dysfunction with this transition?
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